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Category:Programming tools for WindowsAdvanced Neonatal Intensive Care (ANI) is performed in about 2% of all deliveries in the US, and approximately 10% of all premature births. It is believed that a large percentage of severe cerebral palsy, mental retardation, and developmental delay are caused by extreme variation in the developmental process. Thus, the optimal time of initiation and duration of ANI interventions that are effective in preventing developmental delays and long-term adverse outcomes are not well-defined. We propose to develop a new small animal MRI scanner that will be able to evaluate brain anatomy and function in newborn and fetal sheep at high spatial resolution (100?100?0.5mm). The proposed new system combines features of small-bore 7 Tesla (7T) MR imaging with major advances in gradient coil technology and pulse sequences. It will include a flexible surface receive coil and a pair of coaxial transmit/receive (T/R) coils, resulting in a system capable of performing high resolution MRI of the head and the brain of fetuses in utero. The aims of this application are to (1) design, build and test a surface receive coil array for fetal imaging at 7T; (2) design and build a pair of matched excitation and receive array for fetal imaging at 7T; (3) develop gradient pulse sequences for fetal brain functional mapping at 7T, and image live fetal sheep at 100?100?0.5mm; and (4) test the performance of the coils in fetal animal imaging. PUBLIC HEALTH RELEVANCE: Neonatal intensive care (NIC) and fetal care (FC) are performed in about 2% of all deliveries in the US, and approximately 10% of all premature births. It is believed that a large percentage of severe cerebral palsy, mental retardation, and developmental delay are caused by extreme variation in the developmental process. Thus, the optimal time of initiation and duration of NIC interventions that are effective in preventing developmental delays and long-term adverse outcomes are not well-defined. To understand better the long-term effects of the interventions, we propose to develop a new small animal MRI scanner that will be able to evaluate brain anatomy and function in newborn and fetal sheep at high spatial resolution.Het grootste fenomeen dat het afgelopen decennium voelt is een verdere daling van het waterpeil en dus ac619d1d87
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